P2X<sub>7</sub>Receptor Blockade Prevents ATP Excitotoxicity in Oligodendrocytes and Ameliorates Experimental Autoimmune Encephalomyelitis

Matute, Carlos; Torre, Iratxe; Pérez‐Cerdá, Fernando; Pérez‐Samartín, Alberto; Alberdi, Elena; Etxebarria, Estibaliz; M. Arranz, Amaia; Ravid, Rivka; Rodríguez Antigüedad, Alfredo; Victoria Sánchez‐Gómez, María; Domercq, Marı́a

doi:10.1523/jneurosci.0579-07.2007

Public

P2X7Receptor Blockade Prevents ATP Excitotoxicity in Oligodendrocytes and Ameliorates Experimental Autoimmune Encephalomyelitis

Published in Journal of Neuroscience • Aug 29, 2007

Authors:

Carlos Matute

Iratxe Torre

Fernando Pérez‐Cerdá

Abstract

Oligodendrocyte death and demyelination are hallmarks of multiple sclerosis (MS). Here we show that ATP signaling can trigger oligodendrocyte excitotoxicity via activation of calcium-permeable P2X(7) purinergic receptors expressed by these cells. Sustained activation of P2X(7) receptors in vivo caus...

Subject

Excitotoxicity

Experimental autoimmune encephalomyelitis

Multiple sclerosis

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