Influence of 5'-terminal m7G and 2'-O-methylated residues on messenger ribonucleic acid binding to ribosomes

Removal of 80% of the 5'-terminal 7-methyl-guanosine (m7G) from methylated reovirus mRNA by beta elimination results in a concomitant loss of the ability to bind to wheat germ ribosomes. The mRNA molecules that retain the m7G account for most of the residual binding. Removal of the m7G from all mole... View More