Extension of mismatched 3' termini of DNA is a major determinant of the infidelity of human immunodeficiency virus type 1 reverse transcriptase.

W. Perrino, Fred; D Preston, B; J. Sandell, Linda; A. Loeb, Lawrence

doi:10.1073/pnas.86.21.8343

Public

Extension of mismatched 3' termini of DNA is a major determinant of the infidelity of human immunodeficiency virus type 1 reverse transcriptase.

Published in Proceedings of the National Academy of Sciences • Nov 1, 1989

Authors:

Fred W. Perrino

B D Preston

Linda J. Sandell

Abstract

The unusually high error rate of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) suggests that polymerization errors by this enzyme contribute to the genetic variability of the AIDS virus. We have analyzed the mechanism for HIV-1 RT infidelity by studying two distinct steps that...

Subject

Reverse transcriptase

Biology

Nucleotide

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