Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats

O. McGowan, Patrick; Suderman, Matthew; Sasaki, Aya; Chieh‐Ting Huang, Tony; Hallett, Michael; J. Meaney, Michael; Szyf, Moshe

doi:10.1371/journal.pone.0014739

Public

Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats

Published in PLoS ONE • Feb 28, 2011

Authors:

Patrick O. McGowan

Matthew Suderman

Aya Sasaki

Abstract

BACKGROUND: Maternal care is associated with long-term effects on behavior and epigenetic programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of both rats and humans. In the rat, these effects are reversed by cross-fostering, demonstrating that they are defined by epigenetic r...

Subject

Epigenetics

Biology

DNA methylation

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