8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

Valavanidis, Athanasios; Vlachogianni, Thomais; FIOTAKIS, CONSTANTINOS

doi:10.1080/10590500902885684

Public

8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

Published in Journal of Environmental Science and Health Part C • May 2, 2009

Authors:

Athanasios Valavanidis

Thomais Vlachogianni

CONSTANTINOS FIOTAKIS

Abstract

There is extensive experimental evidence that oxidative damage permanently occurs to lipids of cellular membranes, proteins, and DNA. In nuclear and mitochondrial DNA, 8-hydroxy-2' -deoxyguanosine (8-OHdG) or 8-oxo-7,8-dihydro-2' -deoxyguanosine (8-oxodG) is one of the predominant forms of free radi...

Subject

Oxidative stress

Biomarker

DNA oxidation

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