Intranasal DNA Vaccination Induces Potent Mucosal and Systemic Immune Responses and Cross-protective Immunity Against Influenza Viruses

Torrieri-Dramard, Léa; Lambrecht, Bénédicte; Lage Ferreira, Helena; van den Berg, Thierry; Klatzmann, David; Bellier, Bertrand

doi:10.1038/mt.2010.222

Public

Intranasal DNA Vaccination Induces Potent Mucosal and Systemic Immune Responses and Cross-protective Immunity Against Influenza Viruses

Published in Molecular Therapy • Oct 19, 2010

Authors:

Léa Torrieri-Dramard

Bénédicte Lambrecht

Helena Lage Ferreira

Abstract

The induction of potent virus-specific immune responses at mucosal surfaces where virus transmission occurs is a major challenge for vaccination strategies. In the case of influenza vaccination, this has been achieved only by intranasal delivery of live-attenuated vaccines that otherwise pose safety...

Subject

Immune system

DNA vaccination

Vaccination

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