A Randomized Study of Allopurinol on Endothelial Function and Estimated Glomular Filtration Rate in Asymptomatic Hyperuricemic Subjects with Normal Renal Function

Kanbay, Mehmet; Huddam, Bülent; Azak, Alper; Solak, Yalçın; Kocak Kadioglu, Gulay; Kırbaş, İsmail; Duranay, Murat; Covic, Adrian; J. Johnson, Richard

doi:10.2215/cjn.11451210

Public

A Randomized Study of Allopurinol on Endothelial Function and Estimated Glomular Filtration Rate in Asymptomatic Hyperuricemic Subjects with Normal Renal Function

Published in Clinical Journal of the American Society of Nephrology • Jul 22, 2011

Authors:

Mehmet Kanbay

Bülent Huddam

Alper Azak

Abstract

BACKGROUND AND OBJECTIVES: Endothelial dysfunction is an early manifestation of vascular injury and contributes to the development of atherosclerotic cardiovascular disease. Recent studies have implicated hyperuricemia as a risk factor for cardiovascular disease. We hypothesized that lowering uric a...

Subject

Medicine

Hyperuricemia

Allopurinol

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