Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

Kume, Shinji; Uzu, Takashi; Horiike, Kihachiro; Chin‒Kanasaki, Masami; Isshiki, Keiji; Araki, Shin‐ichi; Sugimoto, Toshiro; Haneda, Masakazu; Kashiwagi, Atsunori; Koya, Daisuke

doi:10.1172/jci41376

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Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

Published in Journal of Clinical Investigation • Mar 24, 2010

Authors:

Shinji Kume

Takashi Uzu

Kihachiro Horiike

Abstract

Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies demonstrate that this process is attenuated by calorie restriction (CR). However, the molecular mechanism that underlies the beneficial effect of CR on mitochondrial dysfunction is unclear. Here, we investigated in mi...

Subject

Autophagy

Sirtuin 1

Hypoxia (environmental)

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