Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS)

P. Hughes, Timothy; Hochhaus, Andreas; Branford, Susan; C. Müller, Martin; Kaeda, Jaspal; Foroni, Letizia; Druker, Brian; Guilhot, François; A. Larson, Richard; G. O’Brien, Stephen; S. Rudoltz, Marc; Mone, Manisha; Wehrle, Elisabeth; Modur, Vijay; M. Goldman, John; P. Radich, Jerald; behalf of the IRIS investigators, on

doi:10.1182/blood-2010-03-273979

Public

Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS)

Published in Blood • Aug 3, 2010

Authors:

Timothy P. Hughes

Andreas Hochhaus

Susan Branford

Abstract

This study examines the prognostic significance of early molecular response using an expanded dataset in chronic myeloid leukemia patients enrolled in the International Randomized Study of Interferon and STI571 (IRIS). Serial molecular studies demonstrate decreases in BCR-ABL transcripts over time. ...

Subject

Internal medicine

Imatinib mesylate

Myeloid leukemia

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