T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

Abstract Rationale T-helper type 2 (Th2) inflammation, mediated by IL-4, IL-5, and IL-13, is considered the central molecular mechanism underlying asthma, and Th2 cytokines are emerging therapeutic targets. However, clinical studies increasingly suggest that asthma is heterogeneous. Objectives To de... View More