Contribution of<i>BRCA1</i>and<i>BRCA2</i>mutations to inherited ovarian cancer

J. Ramus, Susan; Harrington, Patricia; Pye, Carole; A. DiCioccio, Richard; J. Cox, Mark; Garlinghouse-Jones, Kim; Oakley‐Girvan, Ingrid; Jacobs, Ian; M. Hardy, Richard; S. Whittemore, Alice; A.J. Ponder, Bruce; Steven Piver, M.; D.P. Pharoah, Paul; A. Gayther, Simon

doi:10.1002/humu.20599

Public

Contribution ofBRCA1andBRCA2mutations to inherited ovarian cancer

Published in Human Mutation • Aug 9, 2007

Authors:

Susan J. Ramus

Patricia Harrington

Carole Pye

Abstract

A total of 283 epithelial ovarian cancer families from the United Kingdom (UK) and the United States (US) were screened for coding sequence changes and large genomic alterations (rearrangements and deletions) in the BRCA1 and BRCA2 genes. Deleterious BRCA1 mutations were identified in 104 families (...

Subject

Ovarian cancer

BRCA2 Protein

Biology

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