FGF-23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis

Shimada, Takashi; Hasegawa, Hisashi; Yamazaki, Y.; Muto, Takanori; Hino, Rieko; Takeuchi, Yasuhiro; Fujita, Toshiro; Nakahara, Kazuhiko; Fukumoto, Seiji; Yamashita, Takeyoshi

doi:10.1359/jbmr.0301264

Public

FGF-23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis

Published in Journal of Bone and Mineral Research • Mar 1, 2004

Authors:

Takashi Shimada

Hisashi Hasegawa

Y. Yamazaki

Abstract

UNLABELLED: We analyzed the effects of an FGF-23 injection in vivo. FGF-23 caused a reduction in serum 1,25-dihydroxyvitamin D by altering the expressions of key enzymes for the vitamin D metabolism followed by hypophosphatemia. This study indicates that FGF-23 is a potent regulator of the vitamin D...

Subject

Hypophosphatemia

Endocrinology

Internal medicine

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