Impact of Multi-Targeted Antiretroviral Treatment on Gut T Cell Depletion and HIV Reservoir Seeding during Acute HIV Infection

Ananworanich, Jintanat; Schuetz, Alexandra; Vandergeeten, Claire; Sereti, Irini; de Souza, Mark; Rerknimitr, Rungsun; Dewar, Robin; Marovich, Mary; van Griensven, Frits; Sékaly, Rafick‐Pierre; Pinyakorn, Suteeraporn; Phanuphak, Nittaya; Trichavaroj, Rapee; Rutvisuttinunt, Wiriya; Chomchey, Nitiya; Paris, Robert; A. Peel, Sheila; Valcour, Victor; Maldarelli, Frank; Chomont, Nicolas; L. Michael, Nelson; Phanuphak, Praphan; H. Kim, Jerome; behalf of the RV254/SEARCH 010 Study Group, on

doi:10.1371/journal.pone.0033948

Public

Impact of Multi-Targeted Antiretroviral Treatment on Gut T Cell Depletion and HIV Reservoir Seeding during Acute HIV Infection

Published in PLoS ONE • Mar 30, 2012

Authors:

Jintanat Ananworanich

Alexandra Schuetz

Claire Vandergeeten

Abstract

BACKGROUND: Limited knowledge exists on early HIV events that may inform preventive and therapeutic strategies. This study aims to characterize the earliest immunologic and virologic HIV events following infection and investigates the usage of a novel therapeutic strategy. METHODS AND FINDINGS: We p...

Subject

Seeding

Human immunodeficiency virus (HIV)

Virology

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