Impairment of Learning and Memory in Rats Caused by Oxidative Stress and Aging, and Changes in Antioxidative Defense Systems

Fukui, Koji; Onodera, Koji; Shinkai, Tadashi; Suzuki, Shozo; Urano, Shiro

doi:10.1111/j.1749-6632.2001.tb05646.x

Public

Impairment of Learning and Memory in Rats Caused by Oxidative Stress and Aging, and Changes in Antioxidative Defense Systems

Published in Annals of the New York Academy of Sciences • Apr 1, 2001

Authors:

Koji Fukui

Koji Onodera

Tadashi Shinkai

Abstract

To elucidate the influence of oxidative stress on the brain functions during aging, the cognitive performance ability of rats was assessed by using the water-maze test as an oxidative stress before and after hyperoxia. Young rats showed significantly greater learning ability than both old rats and v...

Subject

Oxidative stress

TBARS

Hippocampus

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