Treatment of rheumatoid arthritis with humanized anti–interleukin‐6 receptor antibody: A multicenter, double‐blind, placebo‐controlled trial

Nishimoto, Norihiro; Yoshizaki, Kazuyuki; Miyasaka, Nobuyuki; Yamamoto, Kazuhiko; Kawai, Shinichi; Takeuchi, Tsutomu; Hashimoto, Jun; Azuma, Junichi; Kishimoto, Tadamitsu

doi:10.1002/art.20303

Public

Treatment of rheumatoid arthritis with humanized anti–interleukin‐6 receptor antibody: A multicenter, double‐blind, placebo‐controlled trial

Published in Arthritis & Rheumatism • Jun 1, 2004

Authors:

Norihiro Nishimoto

Kazuyuki Yoshizaki

Nobuyuki Miyasaka

Abstract

OBJECTIVE: Interleukin-6 (IL-6) is a pleiotropic cytokine that regulates the immune response, inflammation, and hematopoiesis. Overproduction of IL-6 plays pathologic roles in rheumatoid arthritis (RA), and the blockade of IL-6 may be therapeutically effective for the disease. This study was underta...

Subject

Medicine

Placebo

Rheumatoid arthritis

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