Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset.

L. King, Christopher; Mahanty, Siddhartha; Kumaraswami, V.; S Abrams, J; Regunathan, J.; Jayaraman, Kunthala; A. Ottesen, Eric; B. Nutman, Thomas

doi:10.1172/jci116752

Public

Cytokine control of parasite-specific anergy in human lymphatic filariasis. Preferential induction of a regulatory T helper type 2 lymphocyte subset.

Published in Journal of Clinical Investigation • Oct 1, 1993

Authors:

Christopher L. King

Siddhartha Mahanty

V. Kumaraswami

Abstract

The immunological mechanisms involved in maintenance of an asymptomatic microfilaremic state (MF) in patients with lymphatic filariasis remain undefined. MF patients have impaired filarial antigen (Ag)-specific lymphocyte proliferation and decreased frequencies (Fo) of Ag-specific T cells, and yet e...

Subject

Immunology

Brugia malayi

Lymphatic system

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