Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations

R. Glossop, John; R. Glossop, John; D. Emes, Richard; D. Emes, Richard; B Nixon, Nicola; B Nixon, Nicola; E. Haworth, Kim; E. Haworth, Kim; Packham, Jon; Packham, Jon; T. Dawes, P.; T. Dawes, P.; A. Fryer, Anthony; A. Fryer, Anthony; L. Mattey, Derek; L. Mattey, Derek; E. Farrell, William; E. Farrell, William

doi:10.4161/epi.29718

Public

Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations

Published in Epigenetics • Jul 7, 2014

Authors:

John R. Glossop

Richard D. Emes

Abstract

Changes to the DNA methylome have been described in patients with rheumatoid arthritis (RA). In previous work, we reported genome-wide methylation differences in T-lymphocyte and B-lymphocyte populations from healthy individuals. Now, using HumanMethylation450 BeadChips to interrogate genome-wide DN...

Subject

DNA methylation

Methylation

Biology

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