Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

Jeltsch, Michael; Kaipainen, Arja; Joukov, Vladimir; Meng, Xiaojuan; Lakso, Merja; Rauvala, Heikki; A. Swartz, Melody; Fukumura, Dai; K. Jain, Rakesh; Alitalo, Kari

doi:10.1126/science.276.5317.1423

Public

Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice

Published in Science • May 30, 1997

Authors:

Michael Jeltsch

Arja Kaipainen

Vladimir Joukov

Abstract

No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial growth factor (VEGF) regulates vascular permeability and angiogenesis, but does not promote lymphangiogenesis. Overexpression of VEGF-C, a ligand of the VEGF receptors VEGFR-3 and VEGFR-2, in t...

Subject

Lymphangiogenesis

Lymphatic system

Vascular endothelial growth factor C

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