The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

Hillmen, Peter; S. Young, Neal; Schubert, Jörg; A. Brodsky, Robert; Socié, Gèrard; Muus, Petra; Röth, Alexander; Szer, Jeff; Elebute, Modupe; Nakamura, Ryotaro; Browne, Paul; M. Risitano, Antonio; Hill, Anita; Schrezenmeier, Hubert; Fu, Chieh‐Lin; P. Maciejewski, Jaroslaw; A. Rollins, Scott; F. Mojcik, Christopher; P. Rother, Russell; Luzzatto, Lucio

doi:10.1056/nejmoa061648

Public

The Complement Inhibitor Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

Published in New England Journal of Medicine • Sep 21, 2006

Authors:

Peter Hillmen

Neal S. Young

Jörg Schubert

Abstract

BACKGROUND: We tested the safety and efficacy of eculizumab, a humanized monoclonal antibody against terminal complement protein C5 that inhibits terminal complement activation, in patients with paroxysmal nocturnal hemoglobinuria (PNH). METHODS: We conducted a double-blind, randomized, placebo-cont...

Subject

Paroxysmal nocturnal hemoglobinuria

Eculizumab

Medicine

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