Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity**

Guénin, Erwann; Hervé, Anne-Cécile; Floch, Virginie; Loisel, Séverine; Yaouanc, Jean‐Jacques; Clément, Jean‐Claude; Férec, Claude; des Abbayes, Hervé

doi:10.1002/(sici)1521-3773(20000204)39:3<629::aid-anie629>3.0.co;2-k

Public

Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity**

Published in Angewandte Chemie International Edition • Feb 4, 2000

Authors:

Erwann Guénin

Anne-Cécile Hervé

Virginie Floch

Abstract

Replacing the ammonium polar head in cationic lipids 1 (A=N) by a phosphonium or an arsonium group (A=P, As) improves their properties as synthetic vectors for DNA transfection. The increased volume of the cationic head is supposed to modify the interactions of the vector with the solvent and DNA.

Subject

Phosphonium

Cationic polymerization

Transfection

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