Thermochemotherapy: synergism between hyperthermia (42-43 degrees) and adriamycin (of bleomycin) in mammalian cell inactivation.

M. Hahn, George; Braun, Jonathan; Har-Kedar, I.

doi:10.1073/pnas.72.3.937

Public

Thermochemotherapy: synergism between hyperthermia (42-43 degrees) and adriamycin (of bleomycin) in mammalian cell inactivation.

Published in Proceedings of the National Academy of Sciences • Mar 1, 1975

Authors:

George M. Hahn

Jonathan Braun

I. Har-Kedar

Abstract

The sensitivity of cells exposed in vitro to the antibiotics bleomycin or adriamycin is only mildly increased at 41 degrees over that seen at 37 degrees. However, at 43 degrees a marked synergism between the effects of hyperthermia and drug is observed. This synergism can also be demonstrated to occ...

Subject

Bleomycin

Hyperthermia

In vivo

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