p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

Jain, Ashish; Lamark, Trond; Sjøttem, Eva; Bowitz Larsen, Kenneth; Atesoh Awuh, Jane; Øvervatn, Aud; McMahon, Michael; D. Hayes, John; Johansen, Terje

doi:10.1074/jbc.m110.118976

Public

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

Published in Journal of Biological Chemistry • May 8, 2010

Authors:

Ashish Jain

Trond Lamark

Eva Sjøttem

Abstract

The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic degradation of ubiquitinated targets, is up-regulated by various stressors. Induction of the p62 gene by oxidative stress is mediated by NF-E2-related factor 2 (NRF2) and, at the same time, p62 protein contributes...

Subject

KEAP1

Transcription factor

Cell biology

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