Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice

Ishikawa, Fumihiko; Yasukawa, Masaki; Lyons, Bonnie; Yoshida, Shuro; Miyamoto, Toshihiro; Yoshimoto, Goichi; Watanabe, Takeshi; Akashi, Koichi; D. Shultz, Leonard; Harada, Mine

doi:10.1182/blood-2005-02-0516

Public

Development of functional human blood and immune systems in NOD/SCID/IL2 receptor γ chainnull mice

Published in Blood • May 27, 2005

Authors:

Fumihiko Ishikawa

Masaki Yasukawa

Bonnie Lyons

Abstract

Here we report that a new nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse line harboring a complete null mutation of the common cytokine receptor gamma chain (NOD/SCID/interleukin 2 receptor [IL2r] gamma(null)) efficiently supports development of functional human hemato-lymphopoie...

Subject

Biology

Haematopoiesis

Nod

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