Amplification of N- <i>myc</i> in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

M. Brodeur, Garrett; C. Seeger, Robert; Schwab, Manfred; Varmus, Harold; Michael Bishop, J.

doi:10.1126/science.6719137

Public

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

Published in Science • Jun 8, 1984

Authors:

Garrett M. Brodeur

Robert C. Seeger

Manfred Schwab

Abstract

A domain of DNA designated N-myc is amplified 20- to 140-fold in human neuroblastoma cell lines but not in cell lines from other tumor types. N-myc has now been found to be amplified in neuroblastoma tissue from 24 of 63 untreated patients (38 percent). The extent of amplification appears to be bimo...

Subject

Neuroblastoma

Gene duplication

N-Myc

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