A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

Murrell, Jill; Farlow, Martin; Ghetti, Bernardino; D. Benson, Merrill

doi:10.1126/science.1925564

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A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

Shared by NobleBlocks on Oct 4, 1991 • 12:00 AM UTC

Authors:

Jill Murrell

Martin Farlow

Bernardino Ghetti

Abstract

Alzheimer's disease is a form of localized amyloidosis characterized by cerebral cortical amyloid plaques, neurofibrillary tangles, and amyloid deposits within the walls of leptomeningeal vessels. Although most cases of Alzheimer's disease are sporadic, kindreds with autosomal-dominant inheritance o...

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