Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus

M. Larsen, Claus; Faulenbach, Mirjam; Vaag, Allan; Vølund, Aage; A. Ehses, Jan; Seifert, Burkhardt; Mandrup‐Poulsen, Thomas; Y. Donath, Marc

doi:10.1056/nejmoa065213

Public

Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus

Published in New England Journal of Medicine • Apr 11, 2007

Authors:

Claus M. Larsen

Mirjam Faulenbach

Allan Vaag

Abstract

BACKGROUND: The expression of interleukin-1-receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the production of interleukin-1beta in human pancreatic beta cells, leading to impaired insulin secretion, decreased cell ...

Subject

Internal medicine

Medicine

Endocrinology

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