Expression of a multidrug resistance gene in human cancers.

LJ, Goldstein; H, Galski; A, Fojo; M, Willingham; SL, Lai; A, Gazdar; R, Pirker; A, Green; W, Crist; GM, Brodeur

doi:10.1093/jnci/81.2.116

Public

Expression of a multidrug resistance gene in human cancers.

Shared by NobleBlocks on Jan 1, 1989 • 12:00 AM UTC

Authors:

Goldstein LJ

Galski H

Fojo A

Abstract

Many cancers have been cured by chemotherapeutic agents. However, other cancers are intrinsically drug resistant, and some acquire resistance following chemotherapy. Cloning of the cDNA for the human MDR1 gene (also known as PGY1), which encodes the multidrug efflux protein P-glycoprotein, has made ...

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