Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes

Xia, Fan; Zuo, Xiaolei; Yang, Renqiang; Xiao, Yi; Kang, Di; Vallée‐Bélisle, Alexis; Gong, Xiong; D. Yuen, Jonathan; B. Y. Hsu, Ben; J. Heeger, Alan; W. Plaxco, Kevin

doi:10.1073/pnas.1005632107

Public

Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes

Published in Proceedings of the National Academy of Sciences • Jun 1, 2010

Authors:

Fan Xia

Xiaolei Zuo

Renqiang Yang

Abstract

We have demonstrated a novel sensing strategy employing single-stranded probe DNA, unmodified gold nanoparticles, and a positively charged, water-soluble conjugated polyelectrolyte to detect a broad range of targets including nucleic acid (DNA) sequences, proteins, small molecules, and inorganic ion...

Subject

Colloidal gold

DNA

Biosensor

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