Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

J. Repa, Joyce; Liang, Guosheng; Ou, Jiafu; K. Bashmakov, Yuriy; A. Lobaccaro, Jean‐Marc; Shimomura, Iichiro; Shan, Bei; S. Brown, Michael; GOLDSTEIN, J; J. Mangelsdorf, David

doi:10.1101/gad.844900

Public

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

Published in Genes & Development • Nov 15, 2000

Authors:

Joyce J. Repa

Guosheng Liang

Jiafu Ou

Abstract

The liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that are bound and activated by oxysterols. These receptors serve as sterol sensors to regulate the transcription of gene products that control intracellular cholesterol homeostasis through catabolism and transport....

Subject

Liver X receptor

Sterol regulatory element-binding protein

Retinoid X receptor

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