Saikosaponin-d inhibits proliferation of DU145 human prostate cancer cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase

Yao, Min; Yang, Jingbo; Cao, Lanqing; Zhang, Lian; P. Qu, S.; Gao, Hongwen

doi:10.3892/mmr.2014.2153

Public

Saikosaponin-d inhibits proliferation of DU145 human prostate cancer cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase

Published in Molecular Medicine Reports • Apr 15, 2014

Authors:

Min Yao

Jingbo Yang

Lanqing Cao

Abstract

Saikosaponin‑d (SSd), a triterpene saponin compound derived from Bupleurum radix, has been shown to have a cytotoxic effect on various cancer cell lines. However, its effect on prostate cancer cells has remained unexplored. The present study reports the apoptosis‑inducing effect of SSd on the DU145 ...

Subject

DU145

Cell cycle

Apoptosis

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