Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Oda, Eri; Ohki, Rieko; Murasawa, Hideki; Nemoto, Jiro; Shibue, Tsukasa; Yamashita, Toshiharu; Tokino, Takashi; Taniguchi, Tadatsugu; Tanaka, Nobuyuki

doi:10.1126/science.288.5468.1053

Public

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

Published in Science • May 12, 2000

Authors:

Eri Oda

Rieko Ohki

Hideki Murasawa

Abstract

A critical function of tumor suppressor p53 is the induction of apoptosis in cells exposed to noxious stresses. We report a previously unidentified pro-apoptotic gene, Noxa. Expression of Noxa induction in primary mouse cells exposed to x-ray irradiation was dependent on p53. Noxa encodes a Bcl-2 ho...

Subject

Mediator

Apoptosis

Bcl-2 family

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