Region-Specific Hierarchy between Atrophy, Hypometabolism, and β-Amyloid (Aβ) Load in Alzheimer's Disease Dementia

La Joie, Renaud; Perrotin, Audrey; Barré, Louisa; Hommet, Caroline; Mézenge, Florence; Ibazizène, Méziane; Camus, Vincent; M. Abbas, Ahmed; Landeau, Brigitte; Guilloteau, Denis; de La Sayette, Vincent; Eustache, Francis; Desgranges, Béatrice; Chételat, Gaël

doi:10.1523/jneurosci.2170-12.2012

Public

Region-Specific Hierarchy between Atrophy, Hypometabolism, and β-Amyloid (Aβ) Load in Alzheimer's Disease Dementia

Published in Journal of Neuroscience • Nov 14, 2012

Authors:

Renaud La Joie

Audrey Perrotin

Louisa Barré

Abstract

Gray matter atrophy, glucose hypometabolism, and β-amyloid Aβ deposition are well-described hallmarks of Alzheimer's disease, but their relationships are poorly understood. The present study aims to compare the local levels of these three alterations in humans with Alzheimer's disease. Structural ma...

Subject

Atrophy

Pathology

Neuroimaging

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