A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination

Klareskog, Lars; Stolt, Patrik; Lundberg, Karin; Källberg, Henrik; Bengtsson, Camilla; Grünewald, Johan; Rönnelid, Johan; Erlandsson Harris, Helena; Ulfgren, Ann‐Kristin; Rantapää‐Dahlqvist, Solbritt; Eklúnd, Anders; Padyukov, Leonid; Alfredsson, Lars

doi:10.1002/art.21575

Public

A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination

Published in Arthritis & Rheumatism • Dec 29, 2005

Authors:

Lars Klareskog

Patrik Stolt

Karin Lundberg

Abstract

OBJECTIVE: To investigate whether smoking and HLA-DR shared epitope (SE) genes may interact in triggering immune reactions to citrulline-modified proteins. METHODS: In a case-control study involving patients with recent-onset rheumatoid arthritis (RA), we studied interactions between a major environ...

Subject

Citrullination

Immunology

Autoimmunity

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