A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination

Klareskog, Lars; Stolt, Patrik; Lundberg, Karin; Källberg, Henrik; Bengtsson, Camilla; Grunewald, Johan; Rönnelid, Johan; Erlandsson Harris, Helena; Ulfgren, Ann‐Kristin; Rantapää‐Dahlqvist, Solbritt; Eklund, Anders; Padyukov, Leonid; Alfredsson, Lars

doi:10.1002/art.21575

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A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination

Shared by NobleBlocks on Dec 28, 2005 • 12:00 AM UTC

Authors:

Lars Klareskog

Patrik Stolt

Karin Lundberg

Abstract

Abstract Objective To investigate whether smoking and HLA–DR shared epitope (SE) genes may interact in triggering immune reactions to citrulline‐modified proteins. Methods In a case–control study involving patients with recent‐onset rheumatoid arthritis (RA), we studied interactions between a major ...

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