Comparison of Atovaquone (566C80) with Trimethoprim-Sulfamethoxazole to Treat Pneumocystis carinii Pneumonia in Patients with AIDS

Hughes, Walter; Leoung, Gifford; Kramer, Françoise; A. Bozzette, Samuel; Safrin, Sharon; Frame, Peter; Clumeck, Nathan; Masur, Henry; J. Lancaster, Danny; K. Chan, Charles; P. Lavelle, James; Rosenstock, Joel; Falloon, Judith; Feinberg, Judith; W. LaFon, Stephen; J. Rogers, Michael; R. Sattler, Fred

doi:10.1056/nejm199305273282103

Public

Comparison of Atovaquone (566C80) with Trimethoprim-Sulfamethoxazole to Treat Pneumocystis carinii Pneumonia in Patients with AIDS

Published in New England Journal of Medicine • May 27, 1993

Authors:

Walter Hughes

Gifford Leoung

Françoise Kramer

Abstract

BACKGROUND: Both trimethoprim-sulfamethoxazole and pentamidine are effective as treatments for Pneumocystis carinii pneumonia, but adverse effects frequently limit their use. Atovaquone (566C80) is a new hydroxynaphthoquinone with activity against P. carinii. METHODS: We conducted a double-blind, mu...

Subject

Atovaquone

Medicine

Trimethoprim

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