Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception

Pereira, Vanessa; Busserolles, Jérôme; Christin, Marine; Devilliers, Maïly; Poupon, Laura; Legha, Wassim; Alloui, Abdelkrim; Aissouni, Youssef; Bourinet, Emmanuel; Lesage, Florian; Eschalier, Alain; Lazdunski, Michel; Noël, Jacques

doi:10.1016/j.pain.2014.09.013

Public

Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception

Published in Pain • Sep 18, 2014

Authors:

Vanessa Pereira

Jérôme Busserolles

Marine Christin

Abstract

Two-pore domain background K(+) channels (K2p or KCNK) produce hyperpolarizing currents that control cell membrane polarity and neuronal excitability throughout the nervous system. The TREK2 channel as well as the related TREK1 and TRAAK channels are mechanical-, thermal- and lipid-gated channels th...

Subject

TRPM8

Allodynia

Nociception

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