Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

Masliah, Eliezer; Rockenstein, Edward; Veinbergs, Isaac; Mallory, Margaret; Hashimoto, Makoto; Takeda, Ayako; Sagara, Yutaka; Sisk, Abbyann; Mucke, Lennart

doi:10.1126/science.287.5456.1265

Public

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

Published in Science • Feb 18, 2000

Authors:

Eliezer Masliah

Edward Rockenstein

Isaac Veinbergs

Abstract

To elucidate the role of the synaptic protein alpha-synuclein in neurodegenerative disorders, transgenic mice expressing wild-type human alpha-synuclein were generated. Neuronal expression of human alpha-synuclein resulted in progressive accumulation of alpha-synuclein-and ubiquitin-immunoreactive i...

Subject

Substantia nigra

Alpha-synuclein

Dopaminergic

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