Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis

Rhee, Soo‐Yon; Luís Blanco, José; R. Jordan, Michael; Taylor, Jonathan; Lemey, Philippe; Varghese, Vici; L Hamers, Raph; Bertagnolio, Silvia; F. Rinke de Wit, Tobias; F. Aghokeng, Avelin; Albert, Jan; Avi, Radko; Ávila‐Ríos, Santiago; Bessong, Pascal; Brooks, James; A. Boucher, Charles; L. Brumme, Zabrina; P. Busch, Michael; Bussmann, Hermann; Chaix, Marie‐Laure; Sik Chin, Bum; Thomas d’Aquin, Toni; De Gascun, Cillian; Derache, Anne; Descamps, Diane; Deshpande, Alaka; F. Djoko, Cyrille; H. Eshleman, Susan; Fleury, Hervé; Frange, Pierre; Fujisaki, Seiichiro; Richard Harrigan, P.; Hattori, Junko; Holguín, África; Hunt, Gillian; Ichimura, Hiroshi; Kaleebu, Pontiano; Katzenstein, David; Kiertiburanakul, Sasisopin; H. Kim, Jérôme; Soon Kim, Sung; Li, Yanpeng; Lutsar, Irja; Morris, Lynn; Ndembi, Nicaise; Peng Ng, Kee; Paranjape, Ramesh; Peeters, Martine; Poljak, Mario; A. Price, Matt; Ragonnet‐Cronin, Manon; Reyes‐Terán, Gustavo; Rolland, Morgane; Sirivichayakul, Sunee; M. Smith, Davey; A. Soares, Marcelo; Soriano, Vincent; Ssemwanga, Deogratius; Stanojević, Maja; A. Stefani, Mariane; Sugiura, Wataru; Sungkanuparph, Somnuek; Tanuri, Amílcar; Keng Tee, Kok; M. Truong, Hong-Ha; van de Vijver, David; Vidal, Nicole; Yang, Chunfu; Yang, Rongge; Yebra, Gonzalo; P. A. Ioannidis, John; Vandamme, Anne‐Mieke; W. Shafer, Robert

doi:10.1371/journal.pmed.1001810

Public

Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis

Published in PLoS Medicine • Apr 7, 2015

Authors:

Soo‐Yon Rhee

José Luís Blanco

Michael R. Jordan

Abstract

BACKGROUND: Regional and subtype-specific mutational patterns of HIV-1 transmitted drug resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines and designing diagnostic assays for use in regions where standard genotypic resistance testing is not affordable. We...

Subject

Drug resistance

Odds ratio

Molecular epidemiology

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