Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

Globisch, Daniel; Münzel, Martin; Müller, Markus; Michalakis, Stylianos; Wagner, Mirko; Koch, Susanne; Brückl, Tobias; Biel, Martin; Carell, Thomas

doi:10.1371/journal.pone.0015367

Public

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

Published in PLoS ONE • Dec 23, 2010

Authors:

Daniel Globisch

Martin Münzel

Markus Müller

Abstract

5-Hydroxymethylcytosine (hmC) was recently detected as the sixth base in mammalian tissue at so far controversial levels. The function of the modified base is currently unknown, but it is certain that the base is generated from 5-methylcytosine (mC). This fuels the hypothesis that it represents an i...

Subject

5-Hydroxymethylcytosine

Demethylation

DNA demethylation

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