Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

Guo, Guangwu; Sun, Xiaojuan; Chen, Chao; Wu, Song; Huang, Peide; Li, Zesong; Dean, Michael; Huang, Yi; Jia, Wenlong; Zhou, Quan; Tang, Aifa; Yang, Zuoquan; Li, Xianxin; Song, Pengfei; Zhao, Xiaokun; Ye, Rui; Zhang, Shiqiang; Lin, Zhao; Qi, Mingfu; Wan, Shengqing; Xie, Liangfu; Fan, Fan; L. Nickerson, Michael; Zou, Xiangjun; Hu, Xueda; Li, Xing; Lv, Zhaojie; Mei, Hongbin; Gao, Shengjie; Yin Liang, Chang; Gao, Zhibo; Lu, Jingxiao; Yu, Yuan; Liu, Chunxiao; Li, Lin; Fang, Xiaodong; Jiang, Zhimao; Yang, Jie; Li, Cailing; Zhao, Xin; Chen, Jing; Zhang, Fang; Lai, Yongqi; Lin, Zheguang; Zhou, Fangjian; Chen, Hao; Chang Chan, Hsiao; Tsang, Shirley; Theodorescu, Dan; Li, Yingrui; Zhang, Xiuqing; Wang, Jian; Yang, Huanming; Yang, Huanming; Gui, Yaoting; Wang, Jun; Wang, Jun; Cai, Zhiming

doi:10.1038/ng.2798

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Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation

Published in Nature Genetics • Oct 13, 2013

Authors:

Guangwu Guo

Xiaojuan Sun

Chao Chen

Abstract

Zhiming Cai and colleagues report whole-genome and whole-exome sequencing of 99 paired tumor-normal samples of transitional cell carcinoma of the bladder. They find that 32% of tumors harbor alterations in genes involved in sister chromatid cohesion, including STAG2, ESPL1, NIPBL, SMC1A and SMC3. Bl...

Subject

Biology

Exome sequencing

Carcinogenesis

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