Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes.

C, Vincent-Fabert; R, Fiancette; E, Pinaud; V, Truffinet; N, Cogné; M, Cogné; Y, Denizot

doi:10.1182/blood-2010-01-264689

Public

Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes.

Shared by NobleBlocks on Jun 10, 2010 • 12:00 AM UTC

Authors:

Vincent-Fabert C

Fiancette R

Pinaud E

Abstract

The immunoglobulin heavy chain locus (IgH) undergoes multiple changes along B-cell differentiation. In progenitor B cells, V(D)J assembly allows expression of μ heavy chains. In mature B cells, class switch recombination may replace the expressed constant (C)μ gene with a downstream C(H) gene. Final...

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