HIV-1 infection and AIDS dementia are influenced by a mutant <i>MCP-1</i> allele linked to increased monocyte infiltration of tissues and MCP-1 levels

González, Enrique; H. Rovin, Brad; Sen, Luisa; E. Cooke, Glen; Dhanda, Rahul; Mummidi, Srinivas; Kulkarni, Hemant; J. Bamshad, Michael; Telles, Vanessa; A. Anderson, Stephanie; Walter, Elizabeth; T. Stephan, Kevin; F. Deucher, Michael; Mangano, Andrea; Bologna, Rosa; S. Ahuja, Seema; J. Dolan, Matthew; K. Ahuja, Sunil

doi:10.1073/pnas.202357499

Public

HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels

Published in Proceedings of the National Academy of Sciences • Oct 8, 2002

Authors:

Enrique González

Brad H. Rovin

Luisa Sen

Abstract

Studies in humans and in experimental models of HIV-1 infection indicate an important role for monocyte chemoattractant protein-1 (MCP-1; also known as CC chemokine ligand 2), a potent chemoattractant and activator of mononuclear phagocytes (MP) in the pathogenesis of HIV-associated dementia (HAD). ...

Subject

Immunology

Allele

Chemokine

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