Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

Kim, Jynho; J. Lee, John; Kim, James; R. Gardner, Dale; A. Beachy, Philip

doi:10.1073/pnas.1006822107

Public

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

Published in Proceedings of the National Academy of Sciences • Jul 12, 2010

Authors:

Jynho Kim

John J. Lee

James Kim

Abstract

Aberrant Hedgehog (Hh) pathway activation has been implicated in cancers of diverse tissues and organs, and the tumor growth-inhibiting effects of pathway antagonists in animal models have stimulated efforts to develop pathway antagonists for human therapeutic purposes. These efforts have focused la...

Subject

Cyclopamine

Smoothened

Hedgehog signaling pathway

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