Targeting CD20+ Aggressive B-cell Non–Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice

Chu, Yaya; Hochberg, Jessica; Yahr, Ashlin; Ayello, Janet; van de Ven, Carmella; J. Barth, Matthew; S. Czuczman, Myron; S. Cairo, Mitchell

doi:10.1158/2326-6066.cir-14-0114

Public

Targeting CD20+ Aggressive B-cell Non–Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells In Vitro and in NSG Mice

Published in Cancer Immunology Research • Dec 9, 2014

Authors:

Yaya Chu

Jessica Hochberg

Ashlin Yahr

Abstract

The prognosis is very dismal for patients with relapsed CD20(+) B-cell non-Hodgkin lymphoma (B-NHL). Facilitating the development of alternative novel therapeutic strategies is required to improve outcomes in patients with recurrent/refractory CD20(+) B-NHL. In this study, we investigated functional...

Subject

CD20

Raji cell

Medicine

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