MDM2 and CDK4 Immunostainings Are Useful Adjuncts in Diagnosing Well-Differentiated and Dedifferentiated Liposarcoma Subtypes

Bui Nguyen Binh, Matthieu; Sastre‐Garau, Xavier; Guillou, Louis; de Pinieux, Gonzague; Terrier, Philippe; Lagacé, Réal; Aurias, Alain; Hostein, Isabelle; Michel Coindre, Jean

doi:10.1097/01.pas.0000170343.09562.39

Public

MDM2 and CDK4 Immunostainings Are Useful Adjuncts in Diagnosing Well-Differentiated and Dedifferentiated Liposarcoma Subtypes

Published in The American Journal of Surgical Pathology • Sep 13, 2005

Authors:

Matthieu Bui Nguyen Binh

Xavier Sastre‐Garau

Louis Guillou

Abstract

Atypical lipomatous tumor/well-differentiated liposarcoma (ALT-WDLPS) and dedifferentiated liposarcoma (DDLPS) may be difficult to distinguish from benign adipose tumors and from poorly differentiated sarcomas, respectively. Genetically, they are characterized by amplification of MDM2 and CDK4 genes...

Subject

Liposarcoma

Mdm2

Gene duplication

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