Spread of HTLV-I Between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton

Igakura, Tadahiko; C. Stinchcombe, Jane; Goon, Peter; P. Taylor, Graham; Weber, Jonathan; M. Griffiths, Gillian; Tanaka, Yuetsu; Osame, Mitsuhiro; R. M. Bangham, Charles

doi:10.1126/science.1080115

Public

Spread of HTLV-I Between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton

Published in Science • Mar 13, 2003

Authors:

Tadahiko Igakura

Jane C. Stinchcombe

Peter Goon

Abstract

Cell contact is required for efficient transmission of human T cell leukemia virus- type 1 (HTLV-I) between cells and between individuals, because naturally infected lymphocytes produce virtually no cell-free infectious HTLV-I particles. However, the mechanism of cell-to-cell spread of HTLV-I is not...

Subject

Cytoskeleton

Virology

Polarization (electrochemistry)

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