RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility

Lai Poon, Kar; Tong Tan, Kar; Wei, Yang; Peng Ng, Chee; Colman, Alan; Korzh, Vladimir; Qin Xu, Xiu

doi:10.1093/cvr/cvs095

Public

RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility

Published in Cardiovascular Research • Feb 15, 2012

Authors:

Kar Lai Poon

Kar Tong Tan

Yang Wei

Abstract

AIMS: The factors responsible for cardiomyopathy are not fully understood. Our studies of the transcriptome of human embryonic stem cell-derived cardiomyocytes identified novel genes up-regulated during cardiac differentiation, including RBM24. We therefore studied how its deficiency affected heart ...

Subject

Sarcomere

Contractility

RNA

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