Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining

Audebert, Marc; Salles, Bernard; Calsou, Patrick

doi:10.1074/jbc.m404524200

Public

Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining

Published in Journal of Biological Chemistry • Oct 22, 2004

Authors:

Marc Audebert

Bernard Salles

Patrick Calsou

Abstract

The efficient repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genomic integrity. In mammalian cells, the nonhomologous end-joining process that represents the predominant repair pathway relies on the DNA-dependent protein kinase (DNA-PK) and the XRCC4-DNA ligase IV compl...

Subject

DNA ligase

XRCC1

Poly ADP ribose polymerase

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