Coronavirus Main Proteinase (3CL
            <sup>pro</sup>
            ) Structure: Basis for Design of Anti-SARS Drugs

Anand, Kanchan; Ziebuhr, John; Wadhwani, Parvesh; R. Mesters, Jeroen; Hilgenfeld, Rolf

doi:10.1126/science.1085658

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Coronavirus Main Proteinase (3CL pro ) Structure: Basis for Design of Anti-SARS Drugs

Shared by NobleBlocks on Jun 13, 2003 • 12:00 AM UTC

Authors:

Kanchan Anand

John Ziebuhr

Parvesh Wadhwani

Abstract

A novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (SARS). The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex, is an attractive target for therapy. We determined crystal struc...

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