Improved Neuroprotective Effects of Resveratrol-Loaded Polysorbate 80-Coated Poly(Lactide) Nanoparticles in MPTP-Induced Parkinsonism

da Rocha Lindner, Gabriela; Bonfanti Santos, Danúbia; Colle, Dirleise; Luiz Gasnhar Moreira, Eduardo; Daniel Prediger, Rui; Farina, Marcelo; Maissar Khalil, Najeh; Mara Mainardes, Rubiana

doi:10.2217/nnm.14.165

Public

Improved Neuroprotective Effects of Resveratrol-Loaded Polysorbate 80-Coated Poly(Lactide) Nanoparticles in MPTP-Induced Parkinsonism

Published in Nanomedicine • Apr 1, 2015

Authors:

Gabriela da Rocha Lindner

Danúbia Bonfanti Santos

Dirleise Colle

Abstract

AIM: This study investigated the neuroprotective effects of resveratrol (RVT)-loaded polysorbate 80 (PS80)-coated poly(lactide) nanoparticles in a mouse model of Parkinson's disease (PD), and compared these effects with those from bulk RVT. METHODS: C57BL/6 mice received for 15 days RVT intraperiton...

Subject

MPTP

Neuroprotection

Neurotoxin

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