Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

Ahmed, Nabil; S. Brawley, Vita; Hegde, Meenakshi; Robertson, Catherine; Ghazi, Alexia; Gerken, Claudia; Liu, Enli; Dakhova, Olga; Ashoori, Aidin; Corder, Amanda; Gray, Tara; Wu, Meng-Fen; Liu, Hao; Hicks, John; Rainusso, Nino; Dotti, Gianpietro; Mei, Zhuyong; Grilley, Bambi; P. Gee, Adrian; M. Rooney, Cliona; K. Brenner, Malcolm; E. Heslop, Helen; S. Wels, Winfried; L. Wang, Lisa; M. Anderson, Peter; Gottschalk, Stephen

doi:10.1200/jco.2014.58.0225

Public

Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

Published in Journal of Clinical Oncology • Mar 23, 2015

Authors:

Nabil Ahmed

Vita S. Brawley

Meenakshi Hegde

Abstract

PURPOSE: The outcome for patients with metastatic or recurrent sarcoma remains poor. Adoptive therapy with tumor-directed T cells is an attractive therapeutic option but has never been evaluated in sarcoma. PATIENTS AND METHODS: We conducted a phase I/II clinical study in which patients with recurre...

Subject

Medicine

Chimeric antigen receptor

Sarcoma

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